Sandhya Jain
College of Dentistry, Indore,India
Title: Optimizing Orthodontic Treatment Using Serum Igf-1 Level And Cervical Staging
Biography
Biography: Sandhya Jain
Abstract
Growth of the craniofacial complex in both magnitude and direction has long been regarded as a key factor for successful orthodontic treatment. Accurate assessment for prediction of future facial growth assists orthodontist in formulating proper treatment plan to achieve the best possible result and long-term stability. Among the various growth indicators skeletal age is considered as the most reliable method as it is closely related to physical growth. Insulin-like growth factor-1 (IGF-1) is one of the main mediators of the actionsof growth hormone in promoting muscular and skeletal growth. The study was conducted on 45 male subjects who were at skeletal maturation stage CS-3, CS-4, and CS-5. Serum IGF-1 levels were estimated from blood samples using chemiluminescence immunoassay (CLIA) method. Highly significant different levels of IGF were found between all cervical stages and post hoc analysis revealed no statistical significant difference in CS-3 and CS-4 therefore, the subjects at CS-3 and CS-4 were combined. New upper and lower bound limits of IGF-1 levels were obtained which were 310 and 360 ng /ml, thus a cut off value of 310ng/ml for various treatment options was derived. So a new combined classification of cervical staging and IGF is proposed for optimizing orthodontic treatment timing.