Bayram Nezihe Aslı
Turgut Ozal University,Turkey
Title: The Relationship between Serum Thiol Levels and Microvascular Complications of Diabetes Mellitus
Biography
Biography: Bayram Nezihe Aslı
Abstract
Aims: The certain pathogenesis of microvascular complications in Type 2 diabetes mellitus (T2DM) is unknown. The first aim of this study was to confirm in terms of thiol/disulfide homeostasis whether there are differences between patients with T2DM and control group. The second aim of this study was to investigate the relationship between serum thiol levels and microvascular complications of diabetes mellitus.
Methods: In total, 160 patients with type 2 DM (T2DM) were recruited and grouped into four groups according to microvascular complications. Native thiol–disulfide exchanges were examined using the automated measurement method newly developed by Erel and Neselioglu.
Results: When compared to the control group, the disulfide level (p<0.001) and disulfide/total thiol ratio (p= 0.031) were lower; while native thiol/total thiol (p= 0.031) ratio was higher in diabetic patients. Both native and total thiols were negatively correlated with glycolysed hemoglobin, duration, and age.
Conclusions: An association between diabetic microvascular complications and thiol/disulfide homeostasis was confirmed.
Key words: thiol/disulfide; homeostasis; DM, neuropathy, nephropathy; retinopathy