Clinical Chemistry

Drug Metabolism and Pharmacokinetics

The "Drug Metabolism and Pharmacokinetics" track at our esteemed conference. This track serves as a crucial platform for professionals dedicated to unraveling the complexities of drug metabolism, pharmacokinetics, and their implications for drug development, efficacy, and safety.

Key topics covered in theDrug Metabolism and Pharmacokinetics track include:

1. Drug Metabolism Pathways: Explore the enzymatic pathways involved in drug metabolism, including phase I (oxidation, reduction, hydrolysis) and phase II (conjugation) reactions, and discuss the role of cytochrome P450 enzymes, UDP-glucuronosyltransferases (UGTs), and other drug-metabolizing enzymes.

2. Pharmacokinetic Parameters and Modeling: Investigate pharmacokinetic parameters such as absorption, distribution, metabolism, and excretion (ADME), and discuss pharmacokinetic modeling approaches, including compartmental modeling, non-compartmental analysis, and physiologically-based pharmacokinetic (PBPK) modeling.

3. Drug-Drug Interactions: Delve into the mechanisms and consequences of drug-drug interactions (DDIs), including enzyme inhibition, induction, and transporter-mediated interactions, and explore strategies for predicting, assessing, and managing DDIs in clinical practice.

4. Pharmacogenetics and Personalized Medicine: Address the role of pharmacogenetics in interindividual variability in drug response, including genetic polymorphisms affecting drug metabolism, pharmacokinetics, and pharmacodynamics, and discuss the implications for personalized medicine and precision dosing.

5. Bioavailability and Bioequivalence Studies: Navigate through bioavailability and bioequivalence studies, including the determination of drug absorption rates, bioavailability parameters (AUC, Cmax), and the design and conduct of bioequivalence trials for generic drug approval.

6. Drug Transporters and Pharmacokinetics: Explore the role of drug transporters such as ATP-binding cassette (ABC) transporters and solute carrier (SLC) transporters in drug disposition and pharmacokinetics, and discuss their impact on drug absorption, distribution, and elimination.