Clinical Chemistry in Therapeutic Drug Monitoring and Pharmacology

Therapeutic drug monitoring (TDM) is essential for optimizing drug efficacy, minimizing toxicity, and ensuring personalized treatment, particularly for medications with narrow therapeutic windows or variable patient responses. This session focuses on the application of clinical chemistry in measuring drug concentrations, assessing pharmacokinetics, and monitoring treatment compliance across a wide range of therapeutic agents, including antibiotics, immunosuppressants, antiepileptics, and oncology drugs. Advanced analytical techniques, such as high-performance liquid chromatography (HPLC), mass spectrometry, and automated immunoassays, are highlighted for their accuracy, sensitivity, and reliability. The session also explores integration of TDM with pharmacogenomics, data analytics, and clinical decision support systems to guide individualized therapy and improve patient outcomes. Challenges such as assay standardization, drug interactions, and interpretation of results in complex clinical scenarios are addressed. By emphasizing translational research and real-world applications, this session demonstrates how clinical chemistry enhances personalized pharmacotherapy, supports safe and effective drug use, and contributes to improved patient care.

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